Cell Type Mapping of Inflammatory Muscle Diseases Highlights Selective Myofiber Vulnerability in Inclusion Body Myositis

Characterization of Heterogeneity in Muscle Fiber Types and Selective Susceptibility in Inclusion Body Myositis With advancing age, the incidence of inflammatory myopathies gradually increases, among which inclusion body myositis (IBM) is the most common type, currently lacking effective treatment methods. Unlike other inflammatory myopathies, IBM ...

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Revealing Endoplasmic Reticulum Stress-Related CAF Subpopulations Associated with Chordoma Progression

Introduction Chordoma is a rare and locally aggressive mesenchymal tumor, believed to originate from the remnant tissues of the primitive notochord. The incidence of chordoma is approximately 0.8 per million, with a predilection for the sacral and skull base regions. Currently, the optimal treatment strategy is maximal safe surgical resection follo...