Epigenetic Activation of SOX11 is Associated with Recurrence and Progression of Ductal Carcinoma In Situ to Invasive Breast Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
SOX11   Ductal Carcinoma In Situ   Invasive Breast Cancer   Recurrence   Epigenetics   Biomarker   Progression  

Epigenetic Activation of Sox11 in Recurrence and Progression of Ductal Carcinoma In Situ Background Ductal Carcinoma In Situ (DCIS) is a non-invasive breast cancer characterized by the excessive proliferation of luminal epithelial cells surrounded by myoepithelial cells. DCIS accounts for approximately 25% of breast cancer screenings, and its poten...

Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation

Medicine, Life Sciences, Cell Biology, Immunology, Genetics, Biophysics,
Gene Regulation   Epigenetics   CRISPR Technology   Genetic Interactions   Transcription Factors  

Bidirectional Epigenetic Editing Reveals Hierarchies in Gene Regulation Background and Research Motivation In the human genome, the role of non-coding elements such as enhancers in gene regulation is widely recognized. However, current CRISPR interference methods still have some limitations in studying non-coding elements and genetic interactions. ...

Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Profiling in Breast Cancer Cell Lines

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Breast Cancer   Epigenetics   Chromatin Accessibility   FOXA1   GRHL2   Cell Lines   Heterogeneity  

Identification of Lineage-Specific Epigenetic Regulators FOXA1 and GRHL2 through Chromatin Accessibility Analysis of Breast Cancer Cell Lines Background Breast cancer is a highly heterogeneous disease currently classified clinically based on gene expression patterns, intrinsic molecular subtypes, and the expression of hormone receptors/human epider...