Carbohydrate Antigen 19-9 (CA19-9) Response After Induction FOLFIRINOX for Locally Advanced Pancreatic Cancer Identifies Patients Who May Benefit from Surgical Exploration: Multicentre, Observational Cohort Study

Medicine, Oncology,
Locally Advanced Pancreatic Cancer   CA19-9   FOLFIRINOX   Surgical Exploration   Prognostic Factors   Survival Rate  

Pancreatic cancer is a highly malignant tumor with an extremely low five-year survival rate, especially for patients with locally advanced pancreatic cancer (LAPC), who have limited treatment options and poor prognosis. LAPC is defined based on the degree of tumor contact with adjacent blood vessels and is often considered “unresectable” at diagnos...

Tumour Deposit Count is an Independent Prognostic Factor in Colorectal Cancer—A Population-Based Cohort Study

Medicine, Oncology,
Colorectal Cancer   Tumour Deposits   Prognostic Factor   Survival Rate   Distant Metastasis  

Colorectal Cancer (CRC) is the third most common malignant tumor worldwide, and its prognosis assessment primarily relies on the TNM staging system. However, the current TNM staging system does not fully account for the presence and count of Tumor Deposits (TDs) in lymph node-positive colorectal cancer. Tumor deposits refer to discrete tumor nodule...

Targeted Delivery of Napabucasin with Radiotherapy Improves Outcomes in Diffuse Midline Glioma

Medicine, Neurology, Oncology,
Diffuse Midline Glioma   Radiotherapy   Napabucasin   Targeted Delivery   Blood-Brain Barrier   Oxidative Stress   Survival Rate  

Targeted Delivery of Napabucasin with Radiotherapy in Diffuse Midline Glioma Background Introduction Diffuse Midline Glioma (DMG) is the most aggressive primary brain tumor in children, with a median survival typically less than one year. Although radiation therapy (RT) is the current standard treatment, it only provides transient symptom relief an...

Circulating Tumor DNA Trajectories Predict Survival in Trifluridine/Tipiracil-Treated Metastatic Colorectal Cancer Patients

Medicine, Oncology,
Circulating Tumor DNA   Metastatic Colorectal Cancer   Trifluridine/Tipiracil   Survival Rate   Molecular Biomarkers   Treatment Response   Prognosis  

ctDNA Trajectories Predict Survival in Trifluridine/Tipiracil-Treated Metastatic Colorectal Cancer Patients Academic Background Metastatic colorectal cancer (mCRC) is one of the leading causes of cancer-related deaths worldwide. Despite recent advancements in diagnosis and treatment, the prognosis for advanced-stage patients remains poor. Triflurid...

Single or Double Induction with 7+3 Containing Standard or High-Dose Daunorubicin for Newly Diagnosed AML: The Randomized DAUNODouble Trial by the Study Alliance Leukemia

Medicine, Hematology, Oncology,
Acute Myeloid Leukemia   Induction Therapy   Randomized Controlled Trial   Daunorubicin   Survival Rate  

Academic Background Acute Myeloid Leukemia (AML) is a malignant blood disorder, with the core of its treatment being induction chemotherapy, typically involving a combination of cytarabine and anthracyclines (such as daunorubicin). Although this treatment regimen has been in use since the 1980s, questions regarding the optimal dose of daunorubicin ...

A Prospective Study of Neoadjuvant Pembrolizumab Plus Chemotherapy for Resectable Esophageal Squamous Cell Carcinoma: The Keystone-001 Trial

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Esophageal Squamous Cell Carcinoma   Neoadjuvant Therapy   Pembrolizumab   Chemotherapy   Survival Rate  

Background and Research Motivation Esophageal Squamous Cell Carcinoma (ESCC) is a highly aggressive cancer, especially in locally advanced stages. Traditional neoadjuvant chemoradiotherapy (NCRT) is the standard treatment method for this type of cancer. Despite its significant therapeutic effects, local recurrence and distant metastasis rates remai...