Identification of People with Lynch Syndrome from Those Presenting with Colorectal Cancer in England: Baseline Analysis of the Diagnostic Pathway

Medicine, Oncology, Cardiovascular System,
Lynch Syndrome   Colorectal Cancer   Molecular Diagnostics   National Health Service   England   DNA Mismatch Repair  

Analysis of Lynch Syndrome Diagnostic Pathway Introduction Lynch Syndrome (LS) is a hereditary cancer susceptibility syndrome that primarily leads to the occurrence of colorectal cancer (CRC), endometrial cancer, and several other types of cancer. Although the incidence of Lynch Syndrome among cancer patients and its importance to public health hav...

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

Synergistic Antitumor Activity by Dual Blockade of CCR1 and CXCR2 Expressed on Myeloid Cells within the Tumor Microenvironment

Medicine, Medical Laboratory Science, Gastroenterology, Oncology, Life Sciences, Biochemistry, Immunology,
CCR1   CXCR2   Colorectal Cancer   Tumor Microenvironment   Dual Blockade   Myeloid Cells   Antitumor Activity  

Achieving Synergistic Antitumor Activity by Dual Blocking of CCR1 and CXCR2 Expression in Myeloid Cells Background Introduction Colorectal Cancer (CRC) poses a global health crisis, with its incidence and mortality rates rapidly rising in recent years. Over the past 15 years, the mortality rate of CRC has increased by more than 30%, and it is expec...

Targeted Activation of Ferroptosis in Colorectal Cancer via LGR4 Targeting Overcomes Acquired Drug Resistance

Chemistry, Medicinal Chemistry, Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
Colorectal Cancer   Ferroptosis   Acquired Drug Resistance   LGR4 Targeting   WNT Signaling Pathway  

Overcoming Acquired Resistance in Colorectal Cancer by Targeting LGR4 Research Background: Acquired drug resistance is a major obstacle in cancer treatment and a leading cause of cancer-related deaths. However, the mechanisms of resistance are diverse, and how to specifically target resistant cancer cells remains a significant clinical challenge. A...