Genetic Risk Stratification and Outcomes Among Treatment-Naive Patients with AML Treated with Venetoclax and Azacitidine

Medicine, Hematology, Oncology,
Acute Myeloid Leukemia   Venetoclax   Azacitidine   Genetic Risk Stratification   Prognostic Model   TP53 Mutation   FLT3-ITD Mutation  

Genetic Risk Stratification and Outcomes Among Treatment-Naive AML Patients Treated with Venetoclax and Azacitidine Academic Background Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, with prognosis closely related to the genetic characteristics of patients. The European LeukemiaNet (ELN) 2017 and 2022 risk stratifica...

Single or Double Induction with 7+3 Containing Standard or High-Dose Daunorubicin for Newly Diagnosed AML: The Randomized DAUNODouble Trial by the Study Alliance Leukemia

Medicine, Hematology, Oncology,
Acute Myeloid Leukemia   Induction Therapy   Randomized Controlled Trial   Daunorubicin   Survival Rate  

Academic Background Acute Myeloid Leukemia (AML) is a malignant blood disorder, with the core of its treatment being induction chemotherapy, typically involving a combination of cytarabine and anthracyclines (such as daunorubicin). Although this treatment regimen has been in use since the 1980s, questions regarding the optimal dose of daunorubicin ...

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry,
Acute Myeloid Leukemia   Stem Cells   Mitochondrial Calcium   Oxidative Phosphorylation   Drug Resistance  

This is an academic paper report on the study of acute myeloid leukemia (AML) stem cells. The study found that venetoclax treatment targeting the BCL-2 protein induces different mitochondrial calcium signaling changes in drug-sensitive and drug-resistant AML stem cells, thereby affecting their oxidative phosphorylation metabolism and survival. The ...