Inflammasome Activation Mediates Apoptotic and Pyroptotic Death in Astrocytes under Ischemic Conditions

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
inflammasome   fibrous astrocytes   protoplasmic astrocytes   ischemic stroke   apoptosis   pyroptosis   cell death  

Inflammasome Activation Regulates Apoptosis and Pyroptosis in Astrocytes under Ischemic Conditions Introduction Ischemic stroke is one of the main mechanisms leading to brain damage, characterized by hypoxia and energy deprivation in local brain regions due to interrupted blood flow. In recent years, research has found that inflammatory responses p...

Depleting Profibrotic Macrophages Using Bioactivated In Vivo Assembly Peptides Ameliorates Kidney Fibrosis

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Nephrology, Life Sciences, Cell Biology, Biochemistry, Immunology,
renal fibrosis   immune microenvironment   profibrotic macrophage   bioactivated in vivo assembly   cell death  

Preface Chronic Kidney Disease (CKD) is a condition characterized by long-term damage to kidney structure, leading to gradual loss of kidney function. Currently, about 10% of adults worldwide are affected by CKD, causing approximately 1.2 million deaths annually. Renal fibrosis is one of the pathological manifestations of CKD, characterized by the ...