Predicting circRNA–Disease Associations with Shared Units and Multi-Channel Attention Mechanisms

Information Science, Computer Science, Artificial Intelligence, Life Sciences, Bioengineering,
circRNA   disease association   multi-view learning   attention mechanism   contrastive learning   computational model   bioinformatics  

Background Introduction In recent years, circular RNAs (circRNAs), as a novel class of non-coding RNA molecules, have played a significant role in the occurrence, development, and treatment of diseases. Due to their unique circular structure, circRNAs are resistant to degradation by nucleases, making them potential biomarkers and therapeutic target...

A Deep Learning Approach for Rational Ligand Generation with Toxicity Control

Chemistry, Medicinal Chemistry, Information Science, Artificial Intelligence, Life Sciences, Biochemistry,
deep learning   ligand generation   toxicity control   drug design   computational model   block-based generation   molecular optimization  

Latest Research on Deep Learning Applied to Target Protein Ligand Generation: Proposal and Validation of the DeepBlock Framework Background and Research Problem In the drug discovery process, finding ligand molecules that bind to specific proteins has always been a core objective. However, current virtual screening methods are often limited by the ...

Computational Modeling of Receptive Field Construction in Midget Ganglion Cells of Primate Retina

Medicine, Neurology, Ophthalmology, Life Sciences, Biophysics,
receptive field   midget ganglion cells   primate retina   computational model   center-surround organization   signal processing   color vision  

Computational Modeling Study on the Construction of Receptive Fields in Midget Ganglion Cells of Primate Retina Academic Background The midget pathway in the primate retina is the foundation for high spatial resolution and color perception in the visual system. A key feature of this pathway is the center-surround organization of the receptive field...

The Neurocomputational Mechanism Underlying Decision-Making on Unfairness to Self and Others

Medicine, Basic Medical Sciences, Neurology, Clinical Psychology,
fairness   three-person ultimatum game   fMRI   computational model   multivoxel pattern analysis  

Neural computational mechanisms underlying fairness-based decisions: Self-Unfairness and Other-Unfairness Abstract: Fairness is a fundamental value in human society, and individuals show concern for both self-unfairness and other-unfairness. However, there has been a long-standing debate on whether self-unfairness and other-unfairness evoke shared ...