G-quadruplexes Catalyze Protein Folding by Reshaping the Energetic Landscape

Chemistry, Physical Chemistry, Medicine, Life Sciences, Biochemistry,
protein folding   G-quadruplex   energy landscape   molecular chaperone   nucleic acid  

G-Quadruplexes Catalyze Protein Folding: A Research Report Academic Background Protein folding is a complex and unsolved problem in biology. Many proteins fold very slowly in vitro, far exceeding the time ranges acceptable under physiological conditions. To address this challenge, ATP (adenosine triphosphate)-dependent chaperonins are thought to ac...

Predicting Crystals Formation from Amorphous Precursors Using Deep Learning Potentials

Materials Science, Inorganic Non-Metallic Materials, Information Science, Computer Science, Artificial Intelligence,
deep learning   amorphous precursors   crystal formation   non-crystalline phases   polymorphs   materials science   energy landscape  

Predicting the Emergence of Crystals from Amorphous Precursors: Deep Learning Empowers Breakthroughs in Materials Science Background Introduction The process of crystallization from amorphous materials holds significant importance in both natural and laboratory settings. This phenomenon is widespread in various processes ranging from geological to ...

Deciphering the Topological Landscape of Glioma: A Framework Based on Network Theory

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics,
glioma   glioma stem cell   gene regulatory network   network dynamics   endogenous network theory   energy landscape  

Deciphering the Topological Landscape of Glioma: A Study Based on a Network Theory Framework Glioma stem cells (GSCs) are recognized as key factors in glioma recurrence and treatment resistance, making them an important focus for new therapeutic approaches. However, the limited understanding of the role of GSCs in the hierarchy of glioma has sparke...