Signal Integrator Function of CXXC5 in Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
CXXC5   cell signaling   cancer   targeting therapy   epigenetic regulation   Wnt/β-catenin pathway   TGF-β/BMP pathway  

Signal Integrator Function of CXXC5 in Cancer Academic Background CXXC5 (CXXC-type zinc finger protein 5) is a member of the ZF-CXXC protein family and plays a pivotal role in signal integration and information transfer within the cellular signaling network. By regulating multiple signaling pathways (such as Wnt/β-catenin, TGF-β/BMP, ATM/p53, etc.)...

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Genetics,
single-cell analysis   epigenetic regulation   breast cancer heterogeneity   tamoxifen resistance   core signature   tumor microenvironment   BMP7  

Integrated Single-Cell Analysis Reveals Distinct Epigenetic-Regulated Cancer Cell States and a Heterogeneity-Guided Core Signature in Tamoxifen-Resistant Breast Cancer Academic Background Breast cancer is one of the most common cancers in women, and endocrine therapy (e.g., tamoxifen) is the standard treatment for estrogen receptor α (ER)-positive ...

CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma

Medicine, Basic Medical Sciences, Neurology, Oncology, Life Sciences, Biochemistry, Genetics,
CHD2   glioma   pediatric   neuron interactions   histone mutation   epigenetic regulation  

Research Report on the Regulation of Neuron-Glioma Interactions by CHD2 in Pediatric Gliomas Background High-grade gliomas (HGG) are fatal diseases in both adult and pediatric patients. Recent studies have shown that neuronal activity can promote the progression of various high-grade glioma subgroups. However, the epigenetic mechanisms regulating t...