High-Dimensional Mapping of Human CEACAM1 Expression on Immune Cells and Association with Melanoma Drug Resistance

Medicine, Oncology, Life Sciences, Cell Biology, Bioengineering, Immunology,
CEACAM1   immune cells   melanoma   drug resistance   tumor microenvironment   immune checkpoint  

The Expression of High-Dimensional Mapping of Human CEACAM1 on Immune Cells and Its Association with Melanoma Drug Resistance Research Background Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) is an inhibitory cell surface protein that acts through homophilic and heterophilic ligand binding. The expression of this protein...

LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
LRIG1   VISTA   tumor-specific   CD8+ T cells   immune checkpoint   anti-tumor immunity   immunotherapy  

Immunotherapy Checkpoint Inhibitors (ICIs, also known as immune checkpoint blockers) are a class of drugs that have achieved significant breakthroughs in cancer immunotherapy in recent years. These drugs mainly work by blocking Programmed Death Protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), thereby activating anti-tumor ...