SGLT2 Inhibitor Promotes Ketogenesis to Improve MASH by Suppressing CD8+ T Cell Activation

SGLT2 Inhibitor Promotes Ketogenesis to Improve MASH by Suppressing CD8+ T Cell Activation

Medicine, Hepatobiliary System, Life Sciences, Biochemistry, Immunology,
SGLT2 inhibitor   ketogenesis   CD8+ T cells   MASH   inflammation   liver injury  

Research on SGLT2 Inhibitors Alleviating MASH by Enhancing Ketogenesis to Inhibit CD8+ T Cell Activation Research Background and Problem Positioning Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has become a global health concern. Its severe stage, Metabolic Dysfunction-Associated Steatohepatitis (MASH), leads to hepatocyte damag...

Fusobacterium nucleatum Facilitates Anti-PD-1 Therapy in Microsatellite Stable Colorectal Cancer

Medicine, Basic Medical Sciences, Gastroenterology, Oncology, Life Sciences, Immunology, Microbiology,
microsatellite stable   colorectal cancer   Fusobacterium nucleatum   anti-PD-1 therapy   butyric acid   CD8+ T cells   immunotherapy  

Fusobacterium nucleatum Promotes Anti-PD-1 Therapy in Microsatellite-Stable Colorectal Cancer Background Introduction With the rise of immune checkpoint blockade (ICB) therapy, a new dawn has emerged in cancer treatment. However, despite the approval of PD-1 targeting drugs (e.g., Pembrolizumab) for certain types of colorectal cancer (CRC) patients...

The Role of Combined Anti-PD-1 and Anti-CTLA-4 Therapy in Clonal Responses

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Anti-PD-1   Anti-CTLA-4   Clonal responses   CD8+ T cells   Immunotherapy  

Role of Combined Anti-PD-1 and Anti-CTLA-4 Therapy in Melanoma Immune Response Background Immune checkpoint inhibitors have made significant progress in clinical oncology, especially anti-PD-1 (anti-programmed death protein 1) and anti-CTLA-4 (anti-cytotoxic T-lymphocyte-associated antigen 4) therapies, which have been proven to induce long-term re...

Single-Cell RNA Sequencing and Machine Learning Reveal Relationship Between CD8+ T Cells and Uveal Melanoma Metastasis

Medicine, Oncology,
single-cell RNA sequencing   uveal melanoma   metastasis risk   immune microenvironment   CD8+ T cells   machine learning   tumor microenvironment  

Academic Report on “Machine Learning and Single-cell RNA Sequencing Reveal Relationship Between Intratumor CD8+ T Cells and Uveal Melanoma Metastasis” published in Cancer Cell International in 2024 Research Background and Purpose Uveal melanoma (UM) is the most common intraocular malignant tumor in adults. After receiving radiation or surgical trea...

LRIG1 engages ligand VISTA and impairs tumor-specific CD8+ T cell responses

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
LRIG1   VISTA   tumor-specific   CD8+ T cells   immune checkpoint   anti-tumor immunity   immunotherapy  

Immunotherapy Checkpoint Inhibitors (ICIs, also known as immune checkpoint blockers) are a class of drugs that have achieved significant breakthroughs in cancer immunotherapy in recent years. These drugs mainly work by blocking Programmed Death Protein 1 (PD-1) and Cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), thereby activating anti-tumor ...

Intratumoral Antigen Signaling Traps CD8+ T Cells to Confine Exhaustion to the Tumor Site

Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
cancer immunology   CD8+ T cells   antigen signaling   clonal expansion   T cell exhaustion  

Tumor Immunology Research: The Exhausted State of CD8+ T Cells in Tumors In recent years, immunotherapy has achieved significant progress in the field of tumor treatment. However, tracking the behavior of lymphocytes following antigen signals remains challenging. This study aims to address this issue by developing Antigen Receptor Signaling Reporte...