High Sensitivity of Shotgun Metagenomic Sequencing in Colon Tissue Biopsy by Host DNA Depletion

Medicine, Medical Laboratory Science, Gastroenterology, Life Sciences, Genetics, Microbiology,
host DNA depletion   colon tissue biopsy   shotgun metagenomic sequencing   microbiota   species discovery   disease progression  

High sensitivity of high-throughput metagenomic sequencing in colon tissue biopsies: Eliminating the impact of host DNA Background Evaluating bacterial taxonomic structure through next-generation sequencing without culturing has become a common method for studying the relationship between bacterial imbalance and various diseases. Previous studies h...

Targeting the Intestinal Circadian Clock by Meal Timing Ameliorates Gastrointestinal Inflammation

Medicine, Rheumatology and Immunology, Gastroenterology, Life Sciences, Cell Biology, Immunology, Microbiology,
intestinal circadian clock   gastrointestinal inflammation   IBD   restricted feeding   microbiota  

Research on Alleviating Gastrointestinal Inflammation by Adjusting Intestinal Circadian Rhythm through Feeding Time Background Information Impaired expression of intestinal circadian rhythm genes has been observed in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, such as that occurring in shift worker...

TREM2 Deficiency Reprograms Intestinal Macrophages and Microbiota to Enhance Anti–PD-1 Tumor Immunotherapy

Medicine, Rheumatology and Immunology, Gastroenterology, Oncology, Life Sciences, Cell Biology, Immunology, Microbiology,
TREM2   anti-PD-1   tumor immunotherapy   intestinal macrophages   microbiota  

TREM2 Deficiency Remodels Intestinal Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy A research team from the Washington University School of Medicine, led by Blanda Di Luccia and other scientists, recently published a study in the journal Science Immunology, revealing how intestinal microbiota and tumor-associated macrophages i...