Hormone Therapy Enhances Anti-PD1 Efficacy in Premenopausal Estrogen Receptor-Positive and HER2-Negative Advanced Breast Cancer

Medicine, Rheumatology and Immunology, Endocrinology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
hormone therapy   anti-PD1 antibody   estrogen receptor-positive breast cancer   HER2-negative   immune microenvironment   tumor immunotherapy  

Hormone Therapy Enhances Anti-PD-1 Efficacy: A Breakthrough Study Targeting Estrogen Receptor-Positive/HER2-Negative Metastatic Breast Cancer Background: Why Conduct This Study? In recent years, cancer immunotherapies have achieved transformative success, with notable efficacy in “hot tumors,” such as triple-negative breast cancer (TNBC), which hav...

3D Bioprinting of Tumor Models and Potential Applications

Medicine, Oncology, Life Sciences, Bioengineering,
3D bioprinting   tumor models   tumor microenvironment   bioinks   drug screening   precision medicine   tumor immunotherapy  

3D Bioprinting of Tumor Models and Their Potential Applications: A Review Academic Background Cancer is one of the leading causes of human mortality worldwide. Its uncontrolled abnormal proliferation, rapid growth, metastasis, and high heterogeneity result in extremely low clinical translation rates for traditional two-dimensional (2D) cell culture...

TREM2 Deficiency Reprograms Intestinal Macrophages and Microbiota to Enhance Anti–PD-1 Tumor Immunotherapy

Medicine, Rheumatology and Immunology, Gastroenterology, Oncology, Life Sciences, Cell Biology, Immunology, Microbiology,
TREM2   anti-PD-1   tumor immunotherapy   intestinal macrophages   microbiota  

TREM2 Deficiency Remodels Intestinal Macrophages and Microbiota to Enhance Anti-PD-1 Tumor Immunotherapy A research team from the Washington University School of Medicine, led by Blanda Di Luccia and other scientists, recently published a study in the journal Science Immunology, revealing how intestinal microbiota and tumor-associated macrophages i...