Neoadjuvant Chemotherapy by Liposomal Doxorubicin Boosts Immune Protection of Tumor Membrane Antigens-Based Nanovaccine

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
liposomal doxorubicin   neoadjuvant chemotherapy   tumor membrane antigens   nanovaccine   immune protection   tumor microenvironment   immunotherapy  

Using Liposomal Doxorubicin Neoadjuvant Chemotherapy to Enhance Immune Protection of Tumor Membrane Antigen-Based Nanovaccine Background and Significance Surgical resection remains the primary treatment for solid tumors, but postoperative tumor recurrence and metastasis continue to be major challenges. A promising emerging strategy in personalized ...

PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer

Medicine, Oncology, Life Sciences, Immunology,
breast cancer   radiation therapy   Pembrolizumab   neoadjuvant chemotherapy   biomarkers   HER2-negative   tumor-infiltrating lymphocytes  

Academic Background Breast cancer is one of the most common cancers among women worldwide, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer, which are known for their aggressive nature and poor prognosis. In recent years, immune checkpoint inh...