PEARL: A Phase Ib/II Biomarker Study of Adding Radiation Therapy to Pembrolizumab Before Neoadjuvant Chemotherapy in HER2-Negative Breast Cancer

Medicine, Oncology, Life Sciences, Immunology,
breast cancer   radiation therapy   Pembrolizumab   neoadjuvant chemotherapy   biomarkers   HER2-negative   tumor-infiltrating lymphocytes  

Academic Background Breast cancer is one of the most common cancers among women worldwide, particularly triple-negative breast cancer (TNBC) and hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer, which are known for their aggressive nature and poor prognosis. In recent years, immune checkpoint inh...

Development and Standardization of an Osteoradionecrosis Classification System in Head and Neck Cancer: Implementation of a Risk-Based Model

Medicine, Oncology,
head and neck cancer   osteoradionecrosis   classification system   radiation therapy   risk factors  

Development and Standardization of an Osteoradionecrosis Classification System in Head and Neck Cancer: Implementation Based on Risk Model In recent years, the side effects brought by the treatment of head and neck cancer (HNC), especially radiotherapy, have become a focal point of academic attention. Osteoradionecrosis (ORN) is one of the most sev...

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Temporal Changes in Treatment and Late Mortality and Morbidity in Adult Survivors of Childhood Glioma: A Report from the Childhood Cancer Survivor Study

Medicine, Pediatrics, Neurosurgery, Oncology,
childhood glioma   late mortality   morbidity   radiation therapy   chemotherapy  

This is a long-term outcome study on survivors of pediatric glioma. The main purpose of the study was to evaluate the impact of changes in treatment approaches for pediatric glioma over the past few decades on long-term mortality, chronic health conditions, and subsequent tumor risk among survivors. Background: In the past, treatment for pediatric ...