The Impact of Estrogen Deficiency on Vascularization and Mineralization Dynamics—Insights from a Novel 3D Humanized and Vascularized Bone Organoid Model Academic Background Osteoporosis is a common bone disease, particularly prevalent among postmenopausal women. Osteoporosis not only manifests as a reduction in bone mass but also involves changes i...

Early Malnutrition and the Risk of Osteoporosis in Adulthood: A Large-Scale Cross-Sectional Study Academic Background Osteoporosis is a chronic, systemic metabolic bone disease characterized by reduced bone density and deterioration of bone microstructure, leading to a significantly increased risk of fractures. Globally, approximately 9 million fra...

SIRT5-JIP4 Interaction Promotes Osteoclastogenesis by Modulating RANKL-Induced Signaling Transduction Research Background Osteoporosis is a common bone disease characterized by reduced bone density and disrupted bone microstructure, leading to an increased risk of fractures. Osteoclasts, the primary cells responsible for bone resorption, play a cri...

The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....