Gut Microbial Alterations in Arginine Metabolism Determine Bone Mechanical Adaptation

The Role of Gut Microbial Changes in Lysine Metabolism on Bone Mechanical Adaptation Research Background Osteoporosis, a severe global public health issue, affects over 200 million people, posing significant threats to health and life. Studies have shown that maintaining bone health and preventing osteoporosis are closely linked to mechanical load....

Machine Learning for Automating Subjective Assessment of Arm Movement Abnormality After Acquired Brain Injury

Machine Learning for Automating Subjective Assessment of Arm Movement Abnormality After Acquired Brain Injury

Automated Clinical Assessment of Abnormal Walking Movements in ABI Patients Through Image Extraction and Classification Systems Academic Background Walking disability is a common physical impairment following Acquired Brain Injury (ABI). ABI typically includes stroke and traumatic brain injury, with a global incidence of approximately 1.5 million c...

Safety & Efficacy of a Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation

Safety and Efficacy: The Impact of Robotic Hip Exoskeleton on Outpatient Stroke Rehabilitation Background Stroke is the leading cause of disability among adults in the United States, with up to 80% of stroke survivors experiencing gait impairments, such as reduced walking speed, endurance, and asymmetrical gait, thereby limiting their ability to wa...

Exoskeleton Rehabilitation Robot Training for Balance and Lower Limb Function in Sub-Acute Stroke Patients: A Pilot, Randomized Controlled Trial

The Impact of Exoskeleton Rehabilitation Robot Training on Balance and Lower Limb Function in Subacute Stroke Patients: A Preliminary, Randomized Controlled Trial Research Background and Purpose Stroke is a leading cause of death and disability worldwide. With the rapid development of stroke treatment technology, the mortality rate of stroke has si...

Differential Training Benefits and Motor Unit Remodeling in Wrist Force Precision Tasks Following High and Low Load Blood Flow Restriction Exercises Under Volume-Matched Conditions

Differential Training Benefits and Motor Unit Remodeling in Wrist Force Precision Tasks Following High and Low Load Blood Flow Restriction Exercises Under Volume-Matched Conditions

Study on the Differential Effects of Blood Flow Restriction Training on Strength Gains and Precise Force Control Research Background Blood Flow Restriction (BFR) training, an emerging method for enhancing muscle strength, has garnered attention from researchers and clinical medicine in recent years. BFR training with low-load resistance exercise en...

DDX5 Inhibits Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis via Alternative Splicing and G-Quadruplex Unwinding

The Novel Mechanism of DDX5 in Inhibiting Hyaline Cartilage Fibrosis and Degradation in Osteoarthritis Background Osteoarthritis (OA) is a chronic degenerative disease characterized mainly by the degradation, degeneration, and osteophyte formation of joint cartilage. Hyaline cartilage fibrosis is often considered the end-stage lesion of OA, leading...

Physics-Informed Deep Learning for Musculoskeletal Modeling: Predicting Muscle Forces and Joint Kinematics from Surface EMG

Musculoskeletal models have been widely used in biomechanical analysis because they can estimate motion variables that are difficult to measure directly in living organisms, such as muscle forces and joint moments. Traditional physics-driven computational musculoskeletal models can explain the dynamic interactions between neural inputs to muscles, ...

Distribution of Coronal Plane Alignment of the Knee Classification in Chinese Osteoarthritic and Healthy Population: A Retrospective Cross-sectional Observational Study

A Retrospective Cross-Sectional Observational Study on the Distribution of Coronal Plane Alignment Classifications in Chinese Osteoarthritic and Healthy Populations Research Background Neutral mechanical alignment (MA) of the knee is considered the cornerstone of successful and durable total knee arthroplasty (TKA). However, the existence of “const...

Time of Exercise Differentially Impacts Bone Growth in Mice

Differential Effects of Exercise Timing on Skeletal Growth in Mice Introduction Skeletal growth is crucial for adult height and bone health. Studies have shown that exercise can effectively increase bone density, but the optimal exercise timing remains unclear. This study aimed to investigate the optimal exercise timing by comparing the effects of ...

Characterization of Human Shoulder Joint Stiffness Across 3D Arm Postures and Its Sex Differences

Characterization of Human Shoulder Joint Stiffness Across 3D Arm Postures and Its Sex Differences

Three-Dimensional Postural Characteristics and Gender Differences in Human Shoulder Joint Stiffness Research Background The shoulder joint is one of the most complex joints in the human structure. Its stability is crucial for the effective control of arm movement, including the natural control of distal joints like the elbow and wrist, as well as f...