A Time-Scheduled Oxygen Modulation System Facilitates Bone Regeneration by Powering Periosteal Stem Cells

Academic Background During tissue repair, chronic hypoxia negatively impacts the functionality of stem cells. Periosteal Stem Cells (PSCs), as the primary contributors to bone repair, exhibit unclear behavior under hypoxic conditions. While hypoxia may be beneficial for certain stem cells in the early stages of tissue repair, prolonged hypoxia can ...

A Polyphenol–Metal Network of Propyl Gallate Gallium/Hafnium Oxide on Polyimide Fibers for Facilitating Ligament–Bone Healing

Study on Surface Modification of Polyimide Fibers to Promote Ligament-Bone Healing Academic Background Anterior Cruciate Ligament (ACL) injury is one of the most common sports injuries worldwide, with approximately 1 in 1,250 people requiring ACL reconstruction surgery each year. Currently, the main methods for ACL reconstruction include autografts...

Quantitative Ultrasonic Backscatter Evaluation of Elastic and Mechanical Properties in a Rabbit Tendinopathy Healing Model

Application of Ultrasound Backscatter Technique in Quantitative Tendon Characterization Academic Background Tendinopathy is a common musculoskeletal disease characterized by alterations in the microstructure, composition, and cellular organization of tendons, leading to pain and decreased function. Tendinopathy is typically initiated by overuse and...

Estrogen Deficiency Alters Vascularization and Mineralization Dynamics: Insight from a Novel 3-D Humanized and Vascularized Bone Organoid Model

The Impact of Estrogen Deficiency on Vascularization and Mineralization Dynamics—Insights from a Novel 3D Humanized and Vascularized Bone Organoid Model Academic Background Osteoporosis is a common bone disease, particularly prevalent among postmenopausal women. Osteoporosis not only manifests as a reduction in bone mass but also involves changes i...

Exoskeleton-Assisted Stance and Kneeling Balance and Work Task Evaluation in Construction

Balance and Task Evaluation of Construction Workers Assisted by Knee Exoskeletons Background Introduction Construction workers face serious safety and health risks in hazardous working environments, especially when working at heights. Prolonged standing and kneeling postures can lead to knee injuries, musculoskeletal disorders, and visual disturban...

Influence of Visual-Inertial Sensor-to-Segment Calibration on Upper Limb Joint Angles Estimation

Influence of Visual-Inertial Sensor-to-Segment Calibration on Upper Limb Joint Angles Estimation

Research on Upper Limb Joint Angle Estimation Based on Visual-Inertial Sensors and the Impact of Calibration Methods Academic Background Upper limb dysfunction, especially in post-stroke patients, significantly impacts their ability to perform daily activities. Rehabilitation training is a critical method for restoring upper limb function, but its ...

Minimally Invasive Healing of Bone Implant-Cement Interfaces by Aerogel Cement and Remote Heating

Minimally Invasive Healing of Bone Implant-Cement Interfaces by Aerogel Cement and Remote Heating

Minimally Invasive Repair of Bone Implant-Cement Interfaces Using Aerogel Cement and Remote Heating Background Globally, lower limb fractures are the most common type of bone fracture, particularly among the elderly and patients with osteoporosis. In orthopedic surgery, bone cement is widely used to secure implants for the treatment of long bone fr...

Incorporating Bone-Derived ECM into Macroporous Microribbon Scaffolds to Accelerate Bone Regeneration

Incorporating Bone-Derived Extracellular Matrix (Bone-Derived ECM) into Macroporous Microribbon Scaffolds Accelerates Bone Regeneration Research Report With the continuous progress in the biomedical field, the application of tissue engineering and regenerative medicine in various tissue repairs has become increasingly important. However, research o...

Enhancing Immunomodulation and Osseointegration of Bone Implants via Thrombin-Activated Platelet-Rich Plasma Self-Assembly

Enhancing Immunomodulation and Osseointegration of Bone Implants: A Detailed Overview of Thrombin-Activated Platelet-Rich Plasma (PRP) Self-Assembly Technology Background Introduction To address the challenge of bone defect repair, bone implants play a critical role in modern medicine. However, existing bone implant materials like Polyetheretherket...

Concurrently Bioprinted Scaffolds with Autologous Bone and Allogeneic BMSCs Promote Bone Regeneration through Native BMSC Recruitment

Research on 3D Bioprinted Scaffolds Promoting Bone Regeneration Academic Background In recent years, the incidence of head and craniofacial injuries has significantly increased due to the development of industries and transportation, as well as the frequent occurrence of wars and conflicts. These injuries and related treatments (such as decompressi...