Novel Insight into Atogepant Mechanisms of Action in Migraine Prevention

Medicine, Basic Medical Sciences, Neurology, Neurosurgery, Pharmacy, Life Sciences, Cell Biology,
migraine   headache   trigeminovascular   gepants   central sensitization   pain  

New Research Reveals the Mechanism of Atogepant in Migraine Prevention Background Migraine is a common and highly disruptive neurological disorder affecting millions of people worldwide. Calcitonin Gene-Related Peptide (CGRP) is believed to play a key role in the pathophysiology of migraine. CGRP released from sensory trigeminal ganglia neurons in ...

Sex dimorphism in pain threshold and neuroinflammatory response: the protective effect of female sexual hormones on behavior and seizures in an allergic rhinitis model

Medicine, Rheumatology and Immunology, Neurology, Life Sciences, Immunology,
neuroinflammation   sex dimorphism   DNMT1   IL-17   pain   behavior  

Research Report: The Protective Role of Gender on Pain Threshold and Neuroinflammatory Response in Allergic Rhinitis Model Background Introduction Allergic rhinitis (AR) is an inflammation of the nasal mucosa caused by allergens, affecting approximately 40% of the global population. Rhinitis not only causes physical discomfort but is also often acc...