Matrix Stiffness-Mediated DNA Methylation in Endothelial Cells

In pathological conditions, alterations in tissue mechanical properties are one of the prominent features of many diseases, such as cancer. The tumor vascular system plays a critical role in tumor growth, but its structure and function often become abnormal, manifesting as disorganized, tortuous, and leaky blood vessels. Research has shown that the...

Sex dimorphism in pain threshold and neuroinflammatory response: the protective effect of female sexual hormones on behavior and seizures in an allergic rhinitis model

Research Report: The Protective Role of Gender on Pain Threshold and Neuroinflammatory Response in Allergic Rhinitis Model Background Introduction Allergic rhinitis (AR) is an inflammation of the nasal mucosa caused by allergens, affecting approximately 40% of the global population. Rhinitis not only causes physical discomfort but is also often acc...