Infiltration of M2a Macrophages is Predominant in Genital Verruciform Xanthoma

Predominant Infiltration of M2a Macrophages in Genital Verruciform Xanthoma Academic Background Verruciform xanthoma (VX) is a rare benign verrucous tumor first reported by Sachs in 1903 and formally named by Shafer in 1971. This lesion primarily occurs in the genital area and oral mucosa of elderly individuals. Histopathologically, it is character...

Follicular Lymphoma Comprises Germinal Center–Like and Memory-Like Molecular Subtypes with Prognostic Significance

Progress in Molecular Classification of Follicular Lymphoma: A Dual Typing Predictive Model Based on RNA Sequencing and Immunohistochemistry Follicular Lymphoma (FL) is a B-cell malignancy characterized by a slow clinical progression, with a median overall survival extending up to 20 years. However, the heterogeneous nature of FL leads to significa...

Retrospective Study of Claudin 18 Isoform 2 Prevalence and Prognostic Association in Gastric and Gastroesophageal Junction Adenocarcinoma

Research Report on Claudin 18.2 in Gastric Cancer and Gastroesophageal Junction Adenocarcinoma Background Introduction Gastric cancer and gastroesophageal junction (G/GEJ) adenocarcinoma are major global health burdens. It is estimated that in 2020 alone, there were approximately 1.7 million new cases of gastric and esophageal cancers worldwide, wi...

Decreased Microvascular Claudin-5 Levels in Cerebral Amyloid Angiopathy Associated with Intracerebral Haemorrhage

Study on Cerebral Amyloid Angiopathy (CAA) and the Level of Tight Junction Protein Claudin-5 in Microvessels Background Cerebral Amyloid Angiopathy (CAA) is a disease caused by the deposition of Amyloid-β (Aβ) in the cerebral blood vessels. Research indicates that approximately 23% of individuals over the age of 55 have moderate to severe CAA. CAA ...