Trajectory Alignment of Gene Expression Dynamics

Medicine, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology, Genetics, Microbiology,
gene expression   single-cell transcriptomics   trajectory alignment   bioinformatics   differentially expressed genes  

The advent of single-cell RNA sequencing (scRNA-seq) technology has provided unprecedented resolution for studying gene expression dynamics during cell development and differentiation. However, due to the complexity of biological processes, cell developmental trajectories under different conditions are often asymmetric, posing challenges for data i...

An Organotypic Atlas of Human Vascular Cells

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
vascular cells   single-cell transcriptomics   endothelial cells   mural cells   organotypic   molecular signatures   vascular diseases  

Decoding the Human Vascular System: A Comprehensive Multi-organ Single-cell Transcriptomic Study Reveals Vascular Cell Diversity Background Overview The human vascular system is a core component for sustaining life, comprising endothelial cells (ECs) and mural cells that span across all organ systems. Its functions extend beyond merely delivering b...

Analyzing Embryo Dormancy at Single-Cell Resolution Reveals Dynamic Transcriptional Responses and Activation of Integrin-YAP/TAZ Prosurvival Signaling

Life Sciences, Cell Biology, Biochemistry,
embryo dormancy   single-cell transcriptomics   integrin signaling   YAP/TAZ   developmental potential   mouse embryo   transcriptional dynamics  

Dynamic Transcriptional Response and Activation of Integrin-YAP/TAZ Survival Signaling Pathway Revealed by Single-Cell Resolution Analysis of Embryo Dormancy Introduction Embryo dormancy, or diapause, is a unique reproductive adaptation that allows some mammals to pause embryonic development without compromising their developmental potential. Diapa...