Insulin Receptors in Vascular Smooth Muscle Cells Regulate Plaque Stability of Atherosclerosis

Medicine, Endocrinology, Cardiovascular System,
insulin receptor   smooth muscle cells   atherosclerosis   thrombospondin 1   inflammation   apoptosis   extracellular matrix  

Research Background Cardiovascular diseases (CVD) are one of the leading causes of death worldwide, particularly among patients with diabetes and insulin resistance, where the risk of CVD is significantly elevated. Although the prognosis for diabetic patients has improved in recent years, their CVD-related mortality rate remains 2 to 7 times higher...

METTL14 Promotes Ferroptosis in Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4

Medicine, Cardiovascular System, Life Sciences, Cell Biology, Immunology,
ferroptosis   thoracic aortic aneurysm   smooth muscle cells   METTL14   ACSL4   m6A modification  

Mettl14 Promotes Ferroptosis in Vascular Smooth Muscle Cells During Thoracic Aortic Aneurysm by Stabilizing the m6A Modification of ACSL4 Academic Background Thoracic aortic aneurysm (TAA) is a severe vascular disease that often leads to aortic rupture and acute dissection, with extremely high mortality rates. Currently, the primary treatment for T...