MDGA2 Constrains Glutamatergic Inputs Selectively onto CA1 Pyramidal Neurons to Optimize Neural Circuits for Plasticity, Memory, and Social Behavior

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
MDGA2   CA1 Pyramidal Neurons   Glutamatergic Inputs   Synaptic Plasticity   Memory   Social Behaviors   Autism  

In the field of neuroscience, synaptic organization and plasticity are crucial for cognitive functions such as memory and social behavior. As rare synaptic inhibitory factors, members of the family known as MAM domain-containing glycosylphosphatidylinositol anchor proteins (MDGA) play an important regulatory role in synapse formation by inhibiting ...

Mapping the Behavioral Signatures of Shank3B Mice in Both Sexes

Medicine, Psychiatry, Neurology, Neurosurgery, Life Sciences, Immunology,
Autism   Shank3B   Spontaneous Behavior   3D Animal Motion-Capture System   Computational Ethology   Sex Differences  

Behavioral Characterization of Shank3B Mice Across Both Sexes Research Background Autism Spectrum Disorder (ASD) is a group of complex mental disorders characterized by abnormalities in social interaction and repetitive behaviors. The Shank3B mutant ASD mouse model is widely used in research; however, the behavioral phenotype of this model has not ...

Cortical Gene Expression Architecture links Healthy Neurodevelopment to the Imaging, Transcriptomics and Genetics of Autism and Schizophrenia

Medicine, Psychiatry, Neurology, Life Sciences,
Cortical Gene Expression   Neurodevelopment   Autism   Schizophrenia   Imaging   Transcriptomics   Genetics  

Research Report: The Connection Between Cortical Gene Expression and Neurodevelopmental Disorders Research Background The anatomical and functional organization of the human brain is the result of the coordinated expression of numerous genes. It has been found that the first principal component (c1) of cortical gene expression plays a significant r...

The Effect of TDCS on Inhibitory Control and its Transfer Effect on Sustained Attention in Children with Autism Spectrum Disorder: An fNIRS Study

Medicine, Psychiatry, Neurology, Clinical Psychology, Medical Imaging,
Autism   Inhibitory Control   TDCS   Sustained Attention   fNIRS   Behavioral Intervention  

The Effect of TDCS on Inhibitory Control and Its Transfer Effect on Sustained Attention in Children with Autism Spectrum Disorder: An fNIRS Study Background Autism Spectrum Disorder (ASD) is a type of neurodevelopmental disorder characterized by social communication impairments, narrow interests, and repetitive behaviors. Many studies have found th...