Spatial Patterning Analysis of Cellular Ensembles (SPACE) Detects Complex Spatial Organization at the Cell and Tissue Levels

Spatial Patterning Analysis of Cellular Ensembles (SPACE): Revealing Complex Spatial Patterns in Biological Tissues Academic Background The function of biological tissues depends on the interactions of cells, molecules, and structures in three-dimensional space. Understanding these spatial organization patterns can provide new insights into patholo...

Associations of Microbleeds and Their Topography with Imaging and CSF Biomarkers of Alzheimer Pathology in Individuals with Down Syndrome

Alzheimer’s Disease (AD) and Microbleeds in Down Syndrome (DS) Populations: Their Localization and Association with Imaging and Cerebrospinal Fluid (CSF) Biomarkers This study was conducted by a team led by Sara E. Zsadanyi and Alejandra O. Morcillo-Nieto, with contributors including Mateus R. Aranha, José E. Arriola-Infante, Lídia Vaqué-Alcázar,...

Fluorescence Molecular Tomography Based on Group Sparsity Priori for Morphological Reconstruction of Glioma

Report on the Study of Fluorescence Molecular Tomography for Morphological Reconstruction of Glioma Based on Group Sparsity Priors 1. Academic Background and Research Motivation Fluorescence Molecular Tomography (FMT) is an important tool in life sciences that allows non-invasive real-time three-dimensional (3D) visualization of fluorescence source...

Cortical Gene Expression Architecture links Healthy Neurodevelopment to the Imaging, Transcriptomics and Genetics of Autism and Schizophrenia

Research Report: The Connection Between Cortical Gene Expression and Neurodevelopmental Disorders Research Background The anatomical and functional organization of the human brain is the result of the coordinated expression of numerous genes. It has been found that the first principal component (c1) of cortical gene expression plays a significant r...