Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2–Positive Disease

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Genetics,
breast cancer   brain metastasis   structural rearrangement   cyclin-dependent kinase 12   HER2   genomics   targeted therapy  

Research Report on CDK12 Structural Rearrangements in Brain Metastases of Breast Cancer Background and Purpose Breast Cancer (BC) is the second most common solid tumor involving the Central Nervous System (CNS). Brain Metastases from Breast Cancer (BCBMs) are becoming increasingly common among patients with metastatic breast cancer. Patients with a...

Adeno-Associated Virus-Mediated Trastuzumab Delivery to the Central Nervous System for Human Epidermal Growth Factor Receptor 2+ Brain Metastasis

Medicine, Neurology, Oncology, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Immunology,
Adeno-Associated Virus   Trastuzumab   Central Nervous System   Brain Metastasis   Gene Therapy   Breast Cancer   HER2  

AAV-Mediated Trastuzumab Delivery to the Central Nervous System for EGFR2-Positive Brain Metastases Introduction In the treatment of breast cancer, tumors that are human epidermal growth factor receptor 2 (HER2) positive exhibit more aggressive characteristics, posing significant challenges for clinical treatment. Since the approval of trastuzumab ...