Microglia-specific IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   IL-10   Neuroinflammation   Neurodegeneration   Parkinson's Disease  

Parkinson’s Disease Mouse Model: IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration As research into the pathogenesis of Parkinson’s Disease (PD) deepens, the role of neuroinflammation in PD is gradually being revealed. This study by Simone Bido and his team, published in “Science Translational Medicine”, explores the effects of t...

Microglial PDCD4 Deficiency Mitigates Neuroinflammation-Associated Depression via Facilitating Daxx Mediated PPARγ/IL-10 Signaling

Medicine, Infectious Diseases, Psychiatry, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   PDCD4   Neuroinflammation   Depression   PPARγ   IL-10  

Deletion of Microglia PDCD4 Alleviates Neuroinflammation-Associated Depression by Promoting DAXX-Mediated PPARγ/IL-10 Signaling Background In recent years, neuroinflammatory processes have been demonstrated to be associated with various psychiatric disorders, including schizophrenia, depression, and anxiety. A common feature of these diseases is th...