Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS

Chemistry, Medicinal Chemistry, Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Amyotrophic Lateral Sclerosis   Neurodegeneration   Multifactorial Mechanisms   Drug Combination Therapy   Motor Neuron Protection  

Report on ALS Treatment Study: Exploring the Multifaceted Mechanisms of Nebivolol and Donepezil Background and Research Objectives Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive loss of motor neurons in the spinal cord and brain, leading to severe muscle atrophy, functional decline, and eventual death...

Microglia-specific IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Microglia   IL-10   Neuroinflammation   Neurodegeneration   Parkinson's Disease  

Parkinson’s Disease Mouse Model: IL-10 Gene Delivery Inhibits Neuroinflammation and Neurodegeneration As research into the pathogenesis of Parkinson’s Disease (PD) deepens, the role of neuroinflammation in PD is gradually being revealed. This study by Simone Bido and his team, published in “Science Translational Medicine”, explores the effects of t...

GDF1 Ameliorates Cognitive Impairment Induced by Hearing Loss

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry,
GDF1   Cognitive Function   Hearing Loss   Alzheimer's Disease   Synaptic Function   Neurodegeneration  

Improvement of Cognitive Impairment Induced by Hearing Loss Background Alzheimer’s Disease (AD) is a common dementia characterized by extracellular amyloid plaques formed by aggregation of amyloid-β (Aβ) and intracellular neurofibrillary tangles formed by aggregated tau protein. Epidemiological studies indicate a close correlation between hearing l...