Neuronal AMPK Regulates Microglial Lipid Droplet Accumulation in Tauopathy Brain

Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...

Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...