Failure in a Population: Tauopathy Disrupts Homeostatic Set-Points in Emergent Dynamics Despite Stability in the Constituent Neurons

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry,
Tauopathy   Homeostatic Regulation   Neuronal Dynamics   Neurodegenerative Disease   Network Dynamics  

Disturbance of Neuronal Homeostasis and Disruption of Neuronal Network Dynamics Caused by Tau Proteinopathy Background and Research Objectives Homeostatic mechanisms play a crucial role in maintaining the stability of brain functions. Under normal circumstances, neuronal activity set-points, such as firing rates, are dynamically adjusted through ho...

Neuronal AMPK Regulates Microglial Lipid Droplet Accumulation in Tauopathy Brain

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Bioengineering,
Neurons   AMPK   Lipid Droplets   Tauopathy   Microglia   Neuroinflammation   Lipid Metabolism  

Accumulation of Lipid Droplets in Microglia is Regulated by Neuronal AMPK Background and Research Question Alzheimer’s Disease (AD) is a common type of dementia characterized by neurofibrillary tangles and β-amyloid plaques. However, beyond these classical pathologies, changes in lipid metabolism are increasingly recognized as closely associated wi...

Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Chemistry, Nanoscience, Medicine, Geriatrics, Neurology, Life Sciences, Bioengineering,
NF-κB   NLRP3   Neuroinflammation   Aging   Tauopathy   Cognitive Function  

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...