NCAPD3 Promotes Diffuse Large B-Cell Lymphoma Progression Through Modulating SIRT1 Expression in an H3K9 Monomethylation-Dependent Manner

Medicine, Hematology, Oncology, Life Sciences, Immunology,
NCAPD3   chromatin conformation   SIRT1   H3K9 monomethylation   diffuse large B-cell lymphoma   transcription regulation   mitosis  

Study on the Pro-Cancer Mechanism and Application Value of NCAPD3 in Diffuse Large B-Cell Lymphoma Academic Background Diffuse large B-cell lymphoma (DLBCL) is the most common hematological malignancy, characterized by significant clinical and biological heterogeneity. Although advances in treatment have been made in recent years, a subset of patie...

Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Medicine, Infectious Diseases, Cardiovascular System, Life Sciences, Microbiology,
Klebsiella pneumoniae   extracellular vesicles   endothelial dysfunction   endothelial senescence   SIRT1   hypertension   inflammatory response  

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

SIRT1-RAB7 Axis Attenuates NLRP3 and STING Activation through Late Endosomal-Dependent Mitophagy during Sepsis-Induced Acute Lung Injury

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
acute lung injury   mitophagy   sepsis   SIRT1  

The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...