Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Medicine, Infectious Diseases, Cardiovascular System, Life Sciences, Microbiology,
Klebsiella pneumoniae   extracellular vesicles   endothelial dysfunction   endothelial senescence   SIRT1   hypertension   inflammatory response  

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

SIRT1-RAB7 Axis Attenuates NLRP3 and STING Activation through Late Endosomal-Dependent Mitophagy during Sepsis-Induced Acute Lung Injury

Medicine, Infectious Diseases, Respiratory System, Life Sciences, Cell Biology, Biochemistry, Immunology,
acute lung injury   mitophagy   sepsis   SIRT1  

The SIRT1-Rab7 Axis Regulates NLRP3 and STING Activation in Sepsis-Induced Acute Lung Injury via Terminal Endosome-Dependent Mitophagy Academic Background Acute lung injury (ALI) is one of the leading causes of death in septic patients, primarily due to the pro-inflammatory changes and permeability defects in endothelial cells (ECs). Mitochondrial ...