Klebsiella pneumoniae-derived extracellular vesicles impair endothelial function by inhibiting SIRT1

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

Kindlin-3 but not Talin-1 Contributes to β2 Integrin Clustering

The Critical Role of Kindlin-3 in β2 Integrin Clustering Academic Background Neutrophils are the most abundant type of white blood cells in human blood, and their recruitment is essential for innate immunity and inflammatory responses. The initial and critical step in neutrophil recruitment is their adhesion to vascular endothelial cells, which dep...