Characteristics of Suitable Cases for Nemolizumab Treatment Based on Clinical Findings and Cutaneous Adverse Events Academic Background Atopic Dermatitis (AD) is a common chronic inflammatory skin disease, characterized by intense itching that significantly impacts patients’ quality of life. In recent years, treatment methods for AD have advanced, ...

A Novel Dual-Pipeline Lactate Removal Strategy for Sepsis Treatment Background Sepsis, defined as multi-organ dysfunction caused by a dysregulated host immune response to bloodborne infection, remains a severe global public health issue. Despite advances in modern medicine, the diagnosis and treatment of sepsis pose significant challenges. Statisti...

Application of Electrospun Fibers in Modulating Foreign Body Response Background Introduction In the field of biomedicine, the use of implantable medical devices (such as subcutaneous implants) is becoming increasingly widespread. However, these devices often trigger an immune response in the host after implantation, known as the Foreign Body Respo...

Klebsiella pneumoniae-Derived Extracellular Vesicles Impair Endothelial Function by Inhibiting SIRT1 Academic Background Hypertension is a global health issue with a complex pathogenesis involving multiple factors. In recent years, the role of gut microbiota in hypertension has garnered significant attention. Studies have shown that dysbiosis of th...

The Critical Role of Kindlin-3 in β2 Integrin Clustering Academic Background Neutrophils are the most abundant type of white blood cells in human blood, and their recruitment is essential for innate immunity and inflammatory responses. The initial and critical step in neutrophil recruitment is their adhesion to vascular endothelial cells, which dep...