Translocating Gut Pathobiont Enterococcus Gallinarum Induces Th17 and IgG3 Anti-RNA Directed Autoimmunity in Mouse and Human

Medicine, Rheumatology and Immunology, Nephrology, Life Sciences, Immunology,
autoimmunity   gut microbiota   Th17 cells   IgG3 antibodies   systemic lupus erythematosus  

Academic Background Chronic autoimmune diseases are typically triggered by a combination of genetic predisposition and environmental factors, with complex and incompletely understood mechanisms. In many cases, these diseases require lifelong immunosuppressive treatments, imposing a heavy burden on patients. Recent research has found that gut microb...

TH17 Cell-Intrinsic Glutathione/Mitochondrial-IL-22 Axis Protects Against Intestinal Inflammation

Medicine, Infectious Diseases, Rheumatology and Immunology, Gastroenterology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Th17 cells   glutathione   mitochondria   IL-22   intestinal inflammation   ROS   gut barrier  

Intrinsic Glutathione/Mitochondrial-IL-22 Axis in TH17 Cells and Its Protective Mechanism Against Intestinal Inflammation Background Introduction A large amount of reactive oxygen species (ROS) is generated in the intestine, and the role of T-cell antioxidant mechanisms in maintaining intestinal homeostasis remains unclear. This paper studies the i...

The Role of the IL-1β-Stat5 Axis in Autoimmune Neuroinflammation and Potential Therapeutic Strategies

Medicine, Rheumatology and Immunology, Basic Medical Sciences, Neurology, Life Sciences, Immunology,
autoimmune neuroinflammation   IL-1β   Stat5   steroid resistance   Th17 cells   central nervous system  

Major Breakthrough in Research for Autoimmune Neuroinflammation Treatment Background Introduction Steroid resistance is a significant challenge in the treatment of many inflammatory diseases, particularly autoimmune neuroinflammation. In these diseases, TH17 cells (T helper 17 cells) are widely regarded as key contributors to steroid resistance; ho...