Study on the Apoptosis Induction of Bladder Cancer Stem Cells by Inhibiting Stearoyl-CoA Desaturase

Medicine, Urology, Oncology, Life Sciences, Cell Biology, Biochemistry,
bladder cancer   stearoyl-CoA desaturase   cancer stem cells   lipid metabolism   apoptosis  

Research Background Bladder cancer is a highly prevalent malignant tumor worldwide, ranking as the fourth most common malignancy in men. According to the 2016 report by the National Cancer Center of China (NCCR), bladder cancer ranks sixth in incidence among male malignancies. Despite continuous improvements in medical diagnostic methods and surgic...

Oncogenic Fatty Acid Oxidation Senses Circadian Disruption in Sleep-Deficiency-Enhanced Tumorigenesis

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Cell Biology, Biochemistry,
fatty acid oxidation   circadian disruption   sleep deficiency   tumorigenesis   cancer stem cells   endorphin   chronotherapy  

Fatty Acid Oxidation in Lung Cancer Patients Induced by Sleep Loss Promotes Tumorigenesis Through Circadian Rhythm Disruption Background and Research Motivation Circadian rhythm regulation is one of the critical mechanisms for animals to maintain physiological homeostasis. However, disruptions in circadian rhythms have become a common phenomenon du...

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits CGAS-mediated anticancer immunity

Chemistry, Medicinal Chemistry, Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
PRMT9   cancer stem cells   CGAS   methylation   immune response  

This study revolves around the protein arginine methyltransferase PRMT9, revealing its important role in acute myeloid leukemia (AML) and its potential as an anticancer target. Researchers found that PRMT9 expression levels were significantly elevated in AML stem cells and leukemic cells. Through gene editing and chemical probes, they discovered th...