PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry,
ferroptosis   PRMT5   GPX4   cancer therapy   methylation   tumor progression   antioxidant  

Background Introduction Ferroptosis is a form of cell death triggered by iron-dependent lipid peroxidation, which has recently been recognized as having significant potential in cancer therapy. Cancer cells evade ferroptosis through various molecular alterations and metabolic reprogramming mechanisms, with glutathione peroxidase 4 (GPX4) being a ke...

Dynamic Methylation and Expression of Alternative Promoters for Oestrogen Receptor Alpha in Cell Line Models of Fulvestrant Resistance

Medicine, Endocrinology, Oncology, Life Sciences, Biochemistry,
breast cancer   drug resistance   fulvestrant   methylation   oestrogen receptor   promoter  

Dynamic Changes in Estrogen Receptor Alpha (ERα) Promoter Methylation and Drug Resistance in Breast Cancer Cells Background Breast cancer is one of the most common cancers among women worldwide, with approximately 75% of breast cancer patients expressing estrogen receptor alpha (ERα, gene symbol ESR1). ERα is not only an important prognostic marker...

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits CGAS-mediated anticancer immunity

Chemistry, Medicinal Chemistry, Medicine, Rheumatology and Immunology, Oncology, Life Sciences, Cell Biology, Immunology,
PRMT9   cancer stem cells   CGAS   methylation   immune response  

This study revolves around the protein arginine methyltransferase PRMT9, revealing its important role in acute myeloid leukemia (AML) and its potential as an anticancer target. Researchers found that PRMT9 expression levels were significantly elevated in AML stem cells and leukemic cells. Through gene editing and chemical probes, they discovered th...