Glioma–Astrocyte Connexin43 Confers Temozolomide Resistance Through Activation of the E2F1/ERCC1 Axis

Medicine, Neurology, Pharmacy, Oncology,
glioma   temozolomide resistance   Connexin43   E2F1/ERCC1 axis   tumor microenvironment   astrocytes   chemoresistance  

Study on Connexin43-Mediated Temozolomide Resistance in Glioma through Activation of the E2F1/ERCC1 Axis Academic Background Glioma is the most common and fatal tumor of the central nervous system, with temozolomide (TMZ) being the standard treatment. However, TMZ therapy often leads to tumor recurrence and drug resistance, severely limiting its ef...

Patient-Derived Acellular Ascites Fluid Affects Drug Responses in Ovarian Cancer Cell Lines Through the Activation of Key Signalling Pathways

Medicine, Obstetrics and Gynecology, Oncology, Life Sciences, Immunology,
ovarian cancer   acellular ascites fluid   drug sensitivity   signalling pathways   chemoresistance  

Impact of Patient-Derived Acellular Ascites on Drug Responses in Ovarian Cancer Cell Lines Through Activation of Key Signaling Pathways Background Ovarian cancer is one of the deadliest gynecological malignancies, with a 5-year survival rate of only 30% for patients with advanced epithelial ovarian cancer (EOC). Although surgery and chemotherapy (e...

Targeting a Chemo-Induced Adaptive Signaling Circuit Reveals Therapeutic Vulnerabilities in Pancreatic Cancer

Medicine, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology, Microbiology,
pancreatic cancer   chemoresistance   adaptive signaling circuit   YAP1   COX2  

Targeting Chemotherapy-Induced Adaptive Signaling Circuitry for Therapeutic Potential in Pancreatic Cancer Background Introduction Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal cancer, with a five-year survival rate that remains extremely low. Over 80% of patients are diagnosed at an advanced, unresectable stage, where existin...