Repetitive Administration of Low-Dose Lipopolysaccharide Improves Repeated Social Defeat Stress-Induced Behavioral Abnormalities and Aberrant Immune Response

Medicine, Psychiatry, Neurology, Clinical Psychology, Life Sciences, Biochemistry, Immunology,
lipopolysaccharide   social defeat stress   immune response   behavioral abnormalities   microglia  

Repeated Low-Dose Lipopolysaccharide Pretreatment Improves Behavioral Abnormalities and Aberrant Immune Responses Induced by Repeated Social Defeat Stress Background Stress significantly impacts human health, with chronic stress particularly inducing various physiological and psychological disorders. The hypothalamic-pituitary-adrenal (HPA) axis is...

Park7/DJ-1 Deficiency Impairs Microglial Activation in Response to LPS-Induced Inflammation

Medicine, Neurology, Life Sciences, Cell Biology, Biochemistry, Immunology,
Park7/DJ-1   lipopolysaccharide   microglia   neuroinflammation   Parkinson's disease   microglia morphology  

Important Research Interpretation from “Journal of Neuroinflammation” 2024: The Impact of Park7/DJ-1 Deficiency on Microglial Activation Academic Background Parkinson’s Disease (PD) is the second most common neurodegenerative disease, characterized by the accumulation of α-synuclein and progressive loss of dopaminergic neurons. Aging is the primary...

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming

Medicine, Endocrinology, Neurology, Life Sciences, Biochemistry,
hyperglycemia   neuroinflammation   astrocytes   microglia   lipopolysaccharide   RNA-sequencing   cognitive function  

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming Academic Background Introduction Diabetes is a chronic metabolic disease affecting millions of people worldwide, characterized by hyperglycemia, or elevated blood glucose levels. For a long time, research has primarily focused on ...