Ketones in Cellular Physiology: Metabolic, Signaling, and Therapeutic Advances

Medicine, Geriatrics, Endocrinology, Neurology,
ketones   brain-derived neurotrophic factor   cognitive function   insulin resistance   Alzheimer's disease  

Effects of Exogenous β-Hydroxybutyrate on BDNF Signaling, Cognition, and Amyloid Precursor Protein Processing in Humans with Type 2 Diabetes and Insulin-Resistant Rodents Academic Background Patients with type 2 diabetes (T2D) have a significantly increased risk of developing neurodegenerative diseases, such as Alzheimer’s disease (AD), later in li...

The Maternal X Chromosome Affects Cognition and Brain Ageing in Female Mice

Medicine, Neurology, Life Sciences, Cell Biology, Genetics,
maternal X chromosome   cognitive function   brain ageing   female mice   genomic imprinting   hippocampus   CRISPR  

The Impact of the Maternal X Chromosome on Cognition and Brain Aging in Female Mice Background Introduction In mammals, female cells possess two X chromosomes, one from the mother (maternal X chromosome, Xm) and one from the father (paternal X chromosome, Xp). During embryonic development, one of the X chromosomes is randomly inactivated, a process...

Association between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults without Dementia: A Population-Based Cross-Sectional Analysis

Medicine, Geriatrics, Neurology, Medical Imaging,
choroid plexus   cognitive function   older adults   cerebrospinal fluid   cross-sectional analysis   dementia   brain imaging  

Association Between Choroid Plexus Volume and Cognitive Function in Community-Dwelling Older Adults: A Research Study Academic Background With the increasing global aging population, the number of dementia patients is rising annually. Early identification of older adults with declining cognitive function and guiding them toward preventive and thera...

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming

Medicine, Endocrinology, Neurology, Life Sciences, Biochemistry,
hyperglycemia   neuroinflammation   astrocytes   microglia   lipopolysaccharide   RNA-sequencing   cognitive function  

Hyperglycemia Enhances Brain Susceptibility to Lipopolysaccharide-Induced Neuroinflammation via Astrocyte Reprogramming Academic Background Introduction Diabetes is a chronic metabolic disease affecting millions of people worldwide, characterized by hyperglycemia, or elevated blood glucose levels. For a long time, research has primarily focused on ...

Beta to Theta Power Ratio in EEG Periodic Components as a Potential Biomarker in Mild Cognitive Impairment and Alzheimer's Dementia

Medicine, Basic Medical Sciences, Neurology, Medical Imaging, Life Sciences, Biochemistry,
Alzheimer's dementia   mild cognitive impairment   EEG   periodic EEG power components   biomarkers   cognitive function  

Alzheimer’s Disease Research and Treatment Frontiers: Beta/Theta Power Ratio in EEG Periodic Components as a Potential Biomarker Background Introduction Alzheimer’s dementia (AD) is a progressively developing disease, accounting for 60% to 80% of all dementia cases [1]. In the early stages of AD, mild cognitive impairment (MCI) typically occurs, du...

Associations of Epigenetic Age Estimators with Cognitive Function Trajectories in the Women's Health Initiative Memory Study

Medicine, Geriatrics, Neurology, Life Sciences, Biochemistry, Genetics,
epigenetics   age estimation   cognitive function   women's health   memory  

Association Between Epigenetic Age Acceleration Estimates and Cognitive Trajectories in the Women’s Health Initiative Memory Study Background Maintaining cognitive function is crucial for independent living among older adults. With the growth of the aging population, cognitive decline has become a significant public health challenge. Many studies h...