Spatial Covariance Reveals Isothiocyanate Natural Products Adjust Redox Stress to Restore Function in Alpha-1-Antitrypsin Deficiency

Medicine, Hepatobiliary System, Respiratory System, Pharmacy, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
spatial covariance   isothiocyanate   redox stress   alpha-1-antitrypsin deficiency   natural products   protein folding   nutraceuticals  

Potential Therapeutic Role of Dietary Isothiocyanate Compounds in Alpha-1 Antitrypsin Deficiency (AATD) Background and Significance of the Study Alpha-1 Antitrypsin Deficiency (AATD) is a congenital, monogenic disease primarily caused by the misfolding of alpha-1 antitrypsin (AAT) in the liver. This misfolding leads to two pathological effects: the...

Cryptoic Acids A and B, Benzene-Containing Polyketides, and Cyclocryptamide, a Modified Diketopiperazine, from an Actinomycete of the Genus Cryptosporangium

Chemistry, Organic Chemistry, Medicinal Chemistry, Life Sciences, Biochemistry, Microbiology,
Cryptosporangium   polyketides   diketopiperazine   biological activity   actinomycetes   natural products   drug discovery  

Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...

Celludinone C, a New Dihydroisobenzofuran Isolated from Talaromyces cellulolyticus BF-0307

Chemistry, Medicinal Chemistry, Medicine, Pharmacy, Life Sciences, Biochemistry,
dihydroisobenzofuran   Talaromyces cellulolyticus   SOAT inhibitor   fungal metabolites   structural elucidation   biological activity   natural products  

Discovery of Celludinone C and Its SOAT Inhibitory Activity Academic Background Sterol O-Acyltransferase (SOAT) is an enzyme that catalyzes the esterification of cholesterol and plays a critical role in maintaining intracellular lipid homeostasis. SOAT has two isozymes, SOAT1 and SOAT2, which exhibit significant differences in tissue distribution a...