Novel Benzene-Containing Polyketides and Modified Diketopiperazine from Actinomycete of the Genus Cryptosporangium Academic Background Microbial natural products hold significant value in drug development, particularly actinomycetes, which provide a rich source of various therapeutic compounds, such as aminoglycosides, macrolides, and tetracyclines...

Structure-Function Analysis of 2-Sulfamoylacetic Acid Synthase in Altemicidin Biosynthesis Academic Background Sulfonamide antibiotics, such as altemicidin and its analogs, have garnered significant attention due to their notable antitumor and antibacterial activities. These compounds feature a rare sulfonamide side chain, which holds great importa...

Review of Research on Treatment of Lung Infections with Novel Coumarin Derivatives Background With the increasing antibiotic resistance, especially the problem of Acinetobacter baumannii’s resistance to antibiotics, researchers worldwide have begun to search for new antimicrobial agents. This Gram-negative bacterium, with its high survivability and...

This study was published in the journal Nature Biotechnology, with the doi 10.1038/s41587-024-02267-3. The corresponding authors are Haihong Chen and Yaohong Wang from East China University of Science and Technology, and the publication date is April 26, 2024. The article investigates the high-yield production of chlorophyll through metabolic engin...

Supramolecular Assembly-Activated Single-Molecule Phosphorescence Resonance Energy Transfer for Near-Infrared Targeted Cell Imaging In recent years, pure organic phosphorescence resonance energy transfer (PRET) research has become a hot topic. In this paper, the authors constructed a single-molecule PRET system with a large Stokes shift (367 nm) an...