Minocycline Abrogates Individual Differences in Nerve Injury-Evoked Affective Disturbances in Male Rats and Prevents Associated Supraspinal Neuroinflammation

Medicine, Psychiatry, Neurology,
anhedonia   chronic constriction injury   depression-like behaviour   hippocampus   pain-related disability   radial arm maze  

Chronic Neuropathic Pain Affects Individual Emotional and Behavioral Disorders, Minocycline Shows Antidepressant Effect in Mouse Models Background Chronic Neuropathic Pain (CNP) has a profound impact on patients’ quality of life, but there are significant differences in individual responses to this pain. Some patients exhibit severe pain-related em...

Theta Oscillations Support Prefrontal-Hippocampal Interactions in Sequential Working Memory

Medicine, Neurology, Neurosurgery, Life Sciences, Cell Biology, Biochemistry, Biophysics,
sequential working memory   hippocampus   dorsolateral prefrontal cortex   theta oscillations   stereoelectroencephalography   phase coherence   granger causality  

Study on Theta Oscillations in Hippocampus-Prefrontal Interaction Supporting Sequential Working Memory Academic Background The dorsolateral prefrontal cortex (DLPFC) and the hippocampus play crucial roles in sequential working memory, but the specific interaction mechanisms are not yet clear. Previous studies have shown that these two brain regions...

Circuit-based neuromodulation enhances delayed recall in amnestic mild cognitive impairment

Medicine, Neurology,
neuromodulation   mild cognitive impairment   memory   hippocampus   brain circuits  

Circuit-Based Neuromodulation Enhances Delayed Recall Ability in Patients with Mild Cognitive Impairment Introduction As the aging population increases, amnestic mild cognitive impairment (AMCl) is receiving more attention. AMCl is seen as an important transitional stage from normal cognitive function to dementia and is a hotspot for studying cogni...