The Multifaceted Therapeutical Role of Low-Density Lipoprotein Receptor Family in High-Grade Glioma

Medicine, Neurology, Neurosurgery, Oncology,
Low-Density Lipoprotein Receptor   High-Grade Glioma   Targeted Therapies   Tumorigenesis   Signaling Pathways  

The Multifaceted Therapeutic Role of the Low-Density Lipoprotein Receptor Family in High-Grade Glioma Academic Background High-grade gliomas (HGG) are the most aggressive and prevalent primary brain tumors in the central nervous system (CNS), accounting for approximately 80% of all malignant brain tumors. Among them, glioblastoma (GBM) is the most ...

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Hereditary Hemorrhagic Telangiectasia   Arteriovenous Malformation   Endothelial Cells   mTORC1   Signaling Pathways   Genetic Targeting   Pharmacological Treatment  

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder caused by mutations leading to the loss of function in either Activin Receptor-Like Kinase 1 (ACVRL1) or Endoglin (ENG), which act as receptors a...

Molecular Targets of Glucocorticoids that Elucidate Their Therapeutic Efficacy in Aggressive Lymphomas

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Biochemistry,
Glucocorticoids   Aggressive Lymphomas   B Cell Receptor   Signaling Pathways   Molecular Mechanism  

Analysis of Molecular Targets of Glucocorticoids in the Treatment of Aggressive Lymphomas Academic Background Glucocorticoids (GCs) have been used for over 70 years in the treatment of hematological malignancies, but their mechanisms of action remain unclear. Clinically, glucocorticoids show significant efficacy in treating lymphomas but not in mye...