Different Manifestations of SDH Loss in Adrenal Medulla vs. Fibroblast Models Background Introduction Succinate dehydrogenase (SDH) is a key enzyme in the mitochondrial tricarboxylic acid (TCA) cycle and electron transport chain, responsible for oxidizing succinate to fumarate and participating in electron transfer. SDH consists of four subunits (S...

The Multifaceted Therapeutic Role of the Low-Density Lipoprotein Receptor Family in High-Grade Glioma Academic Background High-grade gliomas (HGG) are the most aggressive and prevalent primary brain tumors in the central nervous system (CNS), accounting for approximately 80% of all malignant brain tumors. Among them, glioblastoma (GBM) is the most ...

Digital Spatial Transcriptomics Highlights DTX3L and BST2 as Crucial Biomarkers in Esophageal Squamous Cell Carcinoma Tumorigenesis Background and Research Question Esophageal cancer (EC) remains a globally prevalent malignant disease with high incidence and mortality rates. Esophageal squamous cell carcinoma (ESCC), the most common histological su...

Discovery of the Recessive Effect of Human Polymerase δ Proofreading Deficiency: Through Mutation Analysis of Normal Cells and Cancer Cells with POLD1 Mutations Background Introduction The disruption of DNA repair is one of the main mechanisms leading to hereditary cancer. Heterozygous pathogenic variants in the exonic regions of POLD1 and POLE aff...

Scientific Paper Report: ENL Mutations Driving Tumor Development This scientific paper, written by Yiman Liu, Qinglan Li, Lele Song, et al., mainly investigates the role of ENL protein mutations in tumor development. This study was published in the 2024 issue of the journal Cancer Discovery. Background Precise control of gene expression is critical...