Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT

Medicine, Hematology, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics,
Hereditary Hemorrhagic Telangiectasia   Arteriovenous Malformation   Endothelial Cells   mTORC1   Signaling Pathways   Genetic Targeting   Pharmacological Treatment  

Genetic and Pharmacological Targeting of mTORC1 in Mouse Models of Arteriovenous Malformation Expose Non-Cell Autonomous Signalling in HHT Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder caused by mutations leading to the loss of function in either Activin Receptor-Like Kinase 1 (ACVRL1) or Endoglin (ENG), which act as receptors a...

A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation, and shortened lifespan

Medicine, Geriatrics, Life Sciences, Immunology,
nutrient signaling   mTORC1   parenchymal damage   myeloid inflammation   lifespan  

Research on the Impact of Nutritional Signals on the Lifespan of Mice Background and Motivation In recent years, the intensification of global aging has posed unprecedented challenges to medicine, socio-economics, and philosophy. By 2050, the global population aged 65 and above is expected to grow from 5% at the beginning of the 20th century to 17%...

Romidepsin Exhibits Anti-Esophageal Squamous Cell Carcinoma Activity Through the DDIT4-mTORC1 Pathway

Medicine, Medical Laboratory Science, Oncology, Life Sciences, Cell Biology, Biochemistry,
Romidepsin   Esophageal Squamous Cell Carcinoma   DDIT4   mTORC1   Drug Screening   Apoptosis   Cell Cycle Arrest  

Romidepsin Exhibits Anti-Esophageal Squamous Cell Carcinoma Activity through DDIT4-mTORC1 Pathway Esophageal squamous cell carcinoma (ESCC) is one of the most common human malignancies globally, with high incidence and mortality rates. Given the limited current treatment options, there is an urgent need to develop new effective therapeutic drugs. I...