Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting Klf2 and T-bet

Medicine, Rheumatology and Immunology, Life Sciences, Cell Biology, Immunology,
NK cells   Eomesodermin   development   Klf2   T-bet  

Spatiotemporal Regulation of KLF2 and T-bet by Eomesodermin During NK Cell Development I. Research Background Natural Killer (NK) cells are important cells in the immune system, capable of recognizing and killing tumor cells and pathogen-infected cells. The generation and development of NK cells depend on the gradual acquisition of a series of spec...

The Effect of B7H6 Ligand on T Cell Responses

Medicine, Infectious Diseases, Rheumatology and Immunology, Oncology, Life Sciences, Immunology,
B7H6   T cells   immune surveillance   NK cells   cancer immunology   antitumor response  

Immunoglobulin Superfamily Ligand B7H6 Enables T Cell Responses under NK Cell Surveillance Background In the field of immunology, understanding the mechanisms regulating T cell immunity is crucial for developing effective therapies for diseases related to T cell dysfunction, such as autoimmune diseases, chronic infections, and cancer. T cells media...

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance Through the IL-6/STAT3 Axis

Medicine, Oncology, Life Sciences, Immunology,
NK cells   MDSC   tumor immune escape   IL-6   STAT3   antigen presentation   immune checkpoint inhibition  

Tumor-Associated NK Cells Drive MDSC-Mediated Tumor Immune Tolerance via the IL-6/STAT3 Axis — Research by Neo et al. In recent years, researchers have delved deeply into the mechanisms of tumor immune escape to improve the success rate of cancer immunotherapy. The accumulation of CD8 T cells in the tumor microenvironment is a critical determinant ...