A mild increase in nutrient signaling to mTORC1 in mice leads to parenchymal damage, myeloid inflammation, and shortened lifespan

Medicine, Geriatrics, Life Sciences, Immunology,
nutrient signaling   mTORC1   parenchymal damage   myeloid inflammation   lifespan  

Research on the Impact of Nutritional Signals on the Lifespan of Mice Background and Motivation In recent years, the intensification of global aging has posed unprecedented challenges to medicine, socio-economics, and philosophy. By 2050, the global population aged 65 and above is expected to grow from 5% at the beginning of the 20th century to 17%...

Inhibition of S6K Lowers Age-Related Inflammation and Increases Lifespan Through the Endolysosomal System

Medicine, Rheumatology and Immunology, Geriatrics, Life Sciences, Cell Biology, Biochemistry, Immunology, Genetics, Biophysics,
S6K   inflammation   lifespan   endolysosomal system   autophagy  

Inhibition of S6K Reduces Age-Related Inflammation and Extends Lifespan through the Endosomal-Lysosomal System Research Background and Problem Description As organisms age, chronic low-grade inflammation (inflammaging) and declined immune function (immunosenescence) become important pathological foundations of many diseases in the elderly, such as ...