Programming Tumor Evolution with Selection Gene Drives to Proactively Combat Drug Resistance

Engineering Selective Gene Drives to Steer Tumor Evolution to Counteract Drug Resistance As tumors evolve, targeted therapies against cancer often fail due to the evolution of drug resistance. This study demonstrates a way to manipulate tumor evolution repeatedly to design therapeutic opportunities, even in the presence of genetic heterogeneity. We...

Study on the Safety and Efficacy of Algorithmically Controlled Electroporation for Treating Spontaneous Equine Melanoma

Study on the Safety and Efficacy of Algorithmically Controlled Electroporation for Treating Spontaneous Equine Melanomas In recent years, electroporation, specifically irreversible electroporation (IRE), has shown significant potential as a non-thermal ablation technique in tumor treatment. Compared to traditional thermal ablation methods, IRE can ...

Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy

Antibody-Displaying Extracellular Vesicles for Targeted Cancer Therapy

The Application of Antibodies Displaying Extracellular Vesicles in Targeted Cancer Therapy Extracellular Vesicles (EVs) have been extensively researched as natural delivery carriers and mediators of biological signals in various tissues. In this study, researchers utilized these characteristics of EVs to demonstrate a modular delivery system for ca...