Peripheral, Central, and Chemotherapy-Induced Neuropathic Changes in Pancreatic Cancer

Medicine, Neurology, Oncology,
pancreatic cancer   neuropathic changes   chemotherapy-induced neuropathy   neural remodeling   neuropathic pain  

Neuropathic Changes in Pancreatic Cancer Academic Background Pancreatic cancer is one of the most lethal cancers today, characterized by late diagnosis and high aggressiveness. Despite some progress in diagnosis and treatment in recent years, the five-year survival rate for pancreatic cancer remains extremely low, at only around 12%. The pathogenes...

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain through Scavenging ROS and Reducing Inflammation

Chemistry, Nanoscience, Medicinal Chemistry, Medicine, Neurology, Life Sciences, Cell Biology, Immunology,
mitochondria   anti-inflammation   neuropathic pain   reactive oxygen species   bimetallic nanozymes   oxidative stress   signaling pathways  

Mitochondria-Targeting Bimetallic Cluster Nanozymes Alleviate Neuropathic Pain by Scavenging ROS and Reducing Inflammation Background Introduction Neuropathic pain is a complex and multifaceted public health issue, with its high incidence and significant negative impact on patients’ quality of life making it a critical area of medical research. Cur...

Human Dorsal Root Ganglia are Either Preserved or Completely Lost After Deafferentation by Brachial Plexus Injury

Medicine, Anesthesiology, Neurology,
brachial plexus injury   dorsal root ganglia   neuropathic pain   RNA-seq   sensory neurone   transcriptome   inflammation  

Paper Title: Human Dorsal Root Ganglia Are Either Preserved or Completely Lost After Deafferentation by Brachial Plexus Injury Authors: Annemarie Sodmann, Johannes Degenbeck, Annemarie Aue, Magnus Schindehütte, Felicitas Schlott, Panagiota Arampatzi, Thorsten Bischler, Max Schneider, Alexander Brack, Camelia M. Monoranu, Tom Gräfenhan, Michael Bohn...

Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-κB/SLICK Pathway

Medicine, Basic Medical Sciences, Neurology, Life Sciences, Cell Biology,
neuropathic pain   circGRIN2B   dorsal root ganglion   inflammation   slick channel  

Mechanism Study of Circular RNA-GRIN2B Inhibiting Neuropathic Pain Background Introduction Neuropathic pain is a persistent pain caused by damage to the somatic sensory nervous system, with its etiology not yet fully understood and clinical treatment facing many difficulties. Given the complexity of neuropathic pain, there is an urgent need to reve...