Abnormal Circadian Rhythms Exacerbate Dilated Cardiomyopathy by Reducing the Ventricular Mechanical Strength

Medicine, Cardiovascular System,
dilated cardiomyopathy   circadian rhythm   sleep apnea   transcriptome   cytoskeleton   fibrosis  

Dilated Cardiomyopathy (DCM) is a cardiac disease characterized by ventricular dilation and systolic dysfunction, and it is one of the primary indications for heart transplantation worldwide. The etiology of DCM is complex, including genetic factors, infections, drugs, toxins, and endocrine disturbances. Due to the heterogeneity of its causes, earl...

Single-Cell Unified Polarization Assessment of Immune Cells

Information Science, Computer Science, Life Sciences, Cell Biology, Immunology,
single-cell RNA sequencing   immune cell polarization   cytokine-driven   computational method   tumor infiltration   transcriptome   cell embeddings  

Immune cells undergo cytokine-driven polarization in response to various stimuli, which alters their transcriptional profiles and functional states. This dynamic process plays a central role in immune responses in both health and disease. However, there has been a lack of systematic methods to assess cytokine-driven polarization in single-cell RNA ...

Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis

Medicine, Obstetrics and Gynecology, Oncology,
borderline ovarian tumor   genomic analysis   ovarian cancer   RNA sequencing   transcriptome   molecular characteristics   tumor microenvironment  

Transcriptomic Concordance Between Borderline Ovarian Tumors and Endometrioid Carcinoma: A Research Study Background Introduction Borderline ovarian tumors (BOTs) are ovarian neoplasms that lie between benign and malignant tumors, typically occurring in young women. Although BOTs are clinically non-invasive, they can occasionally progress to malign...

Human Dorsal Root Ganglia are Either Preserved or Completely Lost After Deafferentation by Brachial Plexus Injury

Medicine, Anesthesiology, Neurology,
brachial plexus injury   dorsal root ganglia   neuropathic pain   RNA-seq   sensory neurone   transcriptome   inflammation  

Paper Title: Human Dorsal Root Ganglia Are Either Preserved or Completely Lost After Deafferentation by Brachial Plexus Injury Authors: Annemarie Sodmann, Johannes Degenbeck, Annemarie Aue, Magnus Schindehütte, Felicitas Schlott, Panagiota Arampatzi, Thorsten Bischler, Max Schneider, Alexander Brack, Camelia M. Monoranu, Tom Gräfenhan, Michael Bohn...

Transcriptome Dynamics and Cell Dialogs Between Oocytes and Granulosa Cells in Mouse Follicle Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
oocyte   granulosa cell   transcriptome   folliculogenesis   cell dialog  

Transcriptome Dynamics and Cell Dialogue Between Oocytes and Granulosa Cells During Mouse Follicle Development Overview Follicle development and maturation is a complex, multi-stage process. During this process, dynamic gene expression in oocytes and surrounding somatic cells, as well as the dialogue between them, play crucial roles. This study rev...

Comprehensive Characterization and Global Transcriptome Analysis of Human Fetal Liver Terminal Erythropoiesis

Medicine, Hepatobiliary System, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
human fetal liver   terminal erythropoiesis   transcriptome   immortalized erythroid cell line   enucleation  

Comprehensive Characterization and Transcriptome Analysis of Terminal Erythropoiesis in Human Fetal Liver Background and Research Question Erythropoiesis is the process of red blood cell production. Initially, “primitive” erythropoiesis occurs in the yolk sac, gradually replaced by “terminal” erythropoiesis in the fetal liver (FL) and postnatal bon...