Single-Cell Transcriptomic Profiling of Heart Reveals ANGPTL4 Linking Fibroblasts and Angiogenesis in Heart Failure with Preserved Ejection Fraction

Medicine, Cardiovascular System, Life Sciences, Cell Biology,
heart failure   single-cell sequencing   ANGPTL4   metabolism   angiogenesis  

Single-Cell Transcriptomics Reveals the Relationship Between Cardiac Fibroblasts and Angiogenesis: The Key Role of ANGPTL4 in HFpEF Background Introduction Heart failure is one of the major global health challenges today. Heart failure is categorized into heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection...

Mapping the Gene Space at Single-Cell Resolution with Gene Signal Pattern Analysis

Life Sciences, Cell Biology, Bioengineering, Genetics,
single-cell sequencing   gene embedding   graph signal processing   bioinformatics   gene co-expression  

Mapping the Gene Space at Single-Cell Resolution: A Study on Gene Signal Pattern Analysis (GSPA) Academic Background Single-cell RNA sequencing (scRNA-seq) technology has made significant progress in biological research in recent years, particularly in revealing the organizational structure of the cellular state space. However, although many comput...

Multiscale Footprints Reveal the Organization of Cis-Regulatory Elements

Information Science, Artificial Intelligence, Life Sciences, Cell Biology, Biochemistry, Bioengineering, Genetics,
cis-regulatory elements   chromatin accessibility   transcription factors   deep learning   single-cell sequencing   genomics   cell differentiation  

Multiscale Footprints Reveal the Role of Cis-Regulatory Elements in Cell Differentiation and Aging Background Introduction The regulation of gene expression is a key mechanism in cell fate determination and disease development, and cis-regulatory elements (CREs) play a crucial role in this process. CREs dynamically regulate gene expression by bindi...

Microglia and Macrophages in Glioblastoma: Landscapes and Treatment Directions

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
glioblastoma   microglia   macrophages   tumor microenvironment   immunotherapy   single-cell sequencing   tumor-associated macrophages  

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

Complex Mosaicism and Aneuploid Cells in Human Embryo Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Genetics,
human embryo   mosaicism   aneuploidy   single-cell sequencing   embryo development  

Study of Complex Mosaicism in Human Embryos: Revealing Extensive Aneuploidy During Early Embryonic Development Background and Research Objectives Pre-implantation Genetic Testing for Aneuploidy (PGT-A) is a widely used technology in in vitro fertilization (IVF) aimed at screening out abnormal embryos to improve implantation and live birth rates. Ho...

Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent glioblastoma

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
glioblastoma   tumor microenvironment   single-cell sequencing   Treg cells   cerebrospinal fluid   immunosuppression   tumor biomarkers  

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...