Microglia and Macrophages in Glioblastoma: Landscapes and Treatment Directions

Medicine, Neurology, Neurosurgery, Oncology, Life Sciences, Immunology,
glioblastoma   microglia   macrophages   tumor microenvironment   immunotherapy   single-cell sequencing   tumor-associated macrophages  

Microglia and Macrophages in Glioblastoma Academic Background Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system, characterized by high invasiveness and lethality. Despite standard treatments such as surgery, chemotherapy, and radiotherapy, the survival rate of patients remains extremely limited, with a medi...

Complex Mosaicism and Aneuploid Cells in Human Embryo Development

Medicine, Obstetrics and Gynecology, Basic Medical Sciences, Life Sciences, Cell Biology, Biochemistry, Genetics,
human embryo   mosaicism   aneuploidy   single-cell sequencing   embryo development  

Study of Complex Mosaicism in Human Embryos: Revealing Extensive Aneuploidy During Early Embryonic Development Background and Research Objectives Pre-implantation Genetic Testing for Aneuploidy (PGT-A) is a widely used technology in in vitro fertilization (IVF) aimed at screening out abnormal embryos to improve implantation and live birth rates. Ho...

Single-cell atlas reveals the immunosuppressive microenvironment and Treg cells landscapes in recurrent glioblastoma

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
glioblastoma   tumor microenvironment   single-cell sequencing   Treg cells   cerebrospinal fluid   immunosuppression   tumor biomarkers  

Single-Cell Atlas Reveals Immunosuppressive Microenvironment and Treg Cell Distribution in Recurrent Glioblastoma Glioblastoma is the most aggressive brain tumor, with a very high recurrence rate and poor prognosis. Although many studies have explored the tumor microenvironment of this disease, the understanding of the immune microenvironment in re...