The Runx2-NLRP3 Axis Orchestrates Matrix Stiffness-Evoked Vascular Smooth Muscle Cell Inflammation

Medicine, Nephrology, Cardiovascular System, Life Sciences, Immunology,
chronic kidney disease   matrix stiffness   NLRP3   Runx2   vascular smooth muscle cell inflammatory phenotype  

Chronic Kidney Disease: Runx2-NLRP3 Axis Regulates Matrix Stiffness-Induced Vascular Smooth Muscle Cell Inflammation Academic Background Chronic Kidney Disease (CKD) is a common condition worldwide, leading to high morbidity and mortality rates among patients and significantly increasing the risk of cardiovascular events. Arterial stiffening, chara...

Inflammatory Mechanisms in Traumatic Brain Injury and Post-Traumatic Epilepsy: A Study

Medicine, Rheumatology and Immunology, Neurology, Neurosurgery, Life Sciences, Biochemistry, Immunology,
Traumatic Brain Injury   Post-Traumatic Epilepsy   Inflammasome Signaling   Microglia   NLRP3  

Neuroinflammation and Epilepsy: The Role of Inflammasomes in Traumatic Brain Injury Background and Purpose Traumatic Brain Injury (TBI) refers to changes in brain function and pathology resulting from physical trauma to the head or neck. Apart from common behavioral and psychological disorders, post-traumatic epilepsy (PTE) is one of the most sever...

Nanoligomers Targeting NF-κB and NLRP3 Reduce Neuroinflammation and Improve Cognitive Function with Aging and Tauopathy

Chemistry, Nanoscience, Medicine, Geriatrics, Neurology, Life Sciences, Bioengineering,
NF-κB   NLRP3   Neuroinflammation   Aging   Tauopathy   Cognitive Function  

Nanopolymer Targeting NF-κB and NLRP3 Reduces Neuroinflammation and Enhances Cognitive Function in Aging and Tauopathy Research Background Aging is a major risk factor for cognitive decline and most neurodegenerative diseases, such as Alzheimer’s disease (AD). These cognitive declines are closely related to the pathological aggregation of Tau prote...