WWP1 Regulates TXNIP Ubiquitination and Degradation in Acute Myeloid Leukemia Cells via Redox State Modulation

Medicine, Hematology, Oncology, Life Sciences, Biochemistry,
acute myeloid leukemia   ubiquitination   redox homeostasis   reactive oxygen species   WWP1   TXNIP   apoptosis  

WWP1 Regulates Redox State in Acute Myeloid Leukemia Cells by Modulating TXNIP Background Acute myeloid leukemia (AML) is a malignant blood disorder characterized by the abnormal proliferation of immature leukemia cells (leukemic blasts) in the bone marrow. Although significant progress has been made in the treatment of AML in recent years, the lon...

BRD4 Inhibitor Reduces Exhaustion and Blocks Terminal Differentiation in CAR-T Cells by Modulating BATF and EGR1

Medicine, Hematology, Oncology, Life Sciences, Cell Biology, Biochemistry, Immunology,
CAR-T cell exhaustion   BRD4 inhibitor   single-cell RNA sequencing   transcriptional factors   acute myeloid leukemia  

Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Although most AML patients achieve complete remission after standard chemotherapy, refractory and relapsed disease remain a significant challenge. Over the past decade, immunotherapy has been widely applied in cancer treatment, particularly chimeric antigen receptor T-cell ...

Multiomic Analysis Identifies Survival Predictors in African American Patients with Acute Myeloid Leukemia

Medicine, Medical Laboratory Science, Hematology, Oncology, Life Sciences, Cell Biology, Immunology, Genetics,
acute myeloid leukemia   African American   gene mutations   inflammation   survival predictors   genomic analysis   multiomic study  

Multi-omics Analysis Reveals Predictors of Survival in African American AML Patients Background and Objectives Acute Myeloid Leukemia (AML) is a hematologic malignancy characterized by clonal expansion of myeloid progenitor cells driven by genomic alterations. Despite advances in genomic profiling, studies focusing on diverse ancestral populations ...

Epitope Editing Protects Hematopoietic Cells from CD123 Immunotherapy for Acute Myeloid Leukemia

Medicine, Hematology, Oncology, Life Sciences, Bioengineering, Immunology, Genetics,
epitope editing   CD123   immunotherapy   acute myeloid leukemia   hematopoietic stem cells   CAR-T  

Epitope Prime Editing Shields Hematopoietic Cells from CD123 Immunotherapy: A Novel Therapeutic Strategy for Acute Myeloid Leukemia Research Background and Problem Statement Acute Myeloid Leukemia (AML) is a malignant blood disease characterized by the abnormal differentiation of myeloid hematopoietic stem and progenitor cells (HSPCs). Its incidenc...

CRISPR dependency screens in primary hematopoietic stem cells identify KDM3B as a genotype-specific vulnerability in IDH2- and TET2-mutant cells

Medicine, Basic Medical Sciences, Oncology, Life Sciences, Biochemistry,
hematopoietic stem cells   KDM3B   epigenetics   clonal hematopoiesis   CRISPR screens   acute myeloid leukemia  

CRISPR-Dependent Screening in Primary Hematopoietic Stem Cells Identifies KDM3B as Specific Susceptibility for IDH2 and TET2 Mutant Genotypes Background and Significance Clonal Hematopoiesis (CH) refers to the abnormal growth of genetically distinct subclones of cells initiated by specific mutations in Hematopoietic Stem Cells (HSCs). This phenomen...

Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML

Medicine, Basic Medical Sciences, Hematology, Oncology, Life Sciences, Biochemistry,
orthogonal proteogenomic   acute myeloid leukemia   EVI1   PA2G4   druggable target   histone deacetylase inhibitors  

Orthogonal Proteogenomic Analysis Identifies Druggable PA2G4-MYC Axis in 3q26 AML Acute myeloid leukemia (AML) is a highly heterogeneous and aggressive malignancy. In particular, the 3q26 chromosomal abnormality subtype of AML has a complex pathogenic mechanism and lacks effective targeted therapies. To address this challenge, Matteo Marchesini and...